Epigenetic Biomarkers for Early Esophageal Cancer Detection in North East India
نویسندگان
چکیده
Esophageal cancer mortality in North East India is strongly associated with the predominant diagnosis of late stage lesions that hampers effective therapy. Molecular biomarkers for early detection of esophageal cancer are an area of utmost concern in order to control the high incidence and mortality due to esophageal cancer in this region. To date there are no molecular biomarkers that have been used for widespread clinical practice. The emergence of epigenetic biomarkers like methylation markers have ushered in a new hope among the cancer researchers providing new insights in biomarker development for risk assessment, early detection and therapeutic stratification. DNA methylation has rapidly emerged as potential biomarkers in body fluids showing promise to assist the clinical management of esophageal cancer. This review provides an overview of DNA methylation, one of the most common epigenetic events, which profoundly contributes to esophageal cancer initiation and progression. Further it highlights the frequently methylated tumor suppressor and DNA repair genes in esophageal cancer. These frequently methylated genes can be used as biomarkers for early detection of esophageal cancer in North East India after proper validation and verification of these biomarkers in the North Eastern
منابع مشابه
Scenario and future prospects of microRNAs in gastric cancer: A review
Carcinoma of the stomach is one of the major prevalent and principal causes of cancer-related deaths worldwide. Current advancement in technology has improved the understanding of the pathogenesis and pathology of gastric cancers (GC). But, high mortality rates, unfavorable prognosis and lack of clinical predictive biomarkers provide an impetus to investigate novel early diagnostic/prognostic m...
متن کاملDetection of Human Papillomavirus DNA by PCR in Esophageal Squamous Cell Carcinoma from Turkmen Sahra, North-East of Iran
Human papillomavirus (HPV) DNA has been identified in esophageal carcinomas. However, the incidence of HPV varies significantly in different geographical locations. In this study, neoplasms from Turkmen Sahra, a region in Golestan province in northeast part of Iran, with a high incidence of squamous cell carcinoma were analyzed for the presence of HPV DNA. Turkmen Sahra is located in the cancer...
متن کاملارزیابی ارتباط تغییرات مکانی توزیع سرطان های مری و معده و وضعیت خاک در استان گلستان
Background and purpose: Cancer is the one common cause of death in developed and the developing countries. Still gastrointestinal cancers is a major cause of Deaths from cancerin the north of the IRAN, this part is a place that located on the Esophageal Cancer belt. As well as is one of esophageal cancer focuses in the world. At the north east of IRAN such as TORKAMAN SAHRA that reaches a maxim...
متن کاملSquamous dysplasia--the precursor lesion for esophageal squamous cell carcinoma.
Esophageal squamous cell carcinoma (ESCC) accounts for 80% of all esophageal cancers worldwide, and esophageal squamous dysplasia (ESD) is the only histopathology that predicts the development of ESCC. The prevalence of ESD parallels rates of invasive ESCC and is typically found in 25% or more of adults above the age of 35 years in populations in north central China, where risk for ESCC is amon...
متن کاملPromoter methylation of MGMT gene in serum of patients with esophageal squamous cell carcinoma in North East India.
BACKGROUND Promoter hypermethylation is a common event in human cancer. O6-methylguanine-DNA methyltransferase (MGMT) is a gene involved in DNA repair, which is methylated in a variety of cancers. We aimed to explore the methylation status of MGMT gene among the North Eastern population where esophageal cancer incidence and exposure to carcinogens like nitrosamines is high. MATERIALS AND METH...
متن کامل